Santa Destroy University is a fictional college in No More Heroes 2: Desperate Struggle. It is located in the city of Santa Destroy, California. UAA assassins Charlie Macdonald and Kimmy Howell are students of the school. The quality of education available at Destroy University is questionable, but it is most likely still abysmal. Despite this, Destroy University is elegantally designed, as it resembles a stereotypical New England private school. The Pizza Batt corporation appears to have funded the university, as a Pizza Batt kiosk can be seen on campus. The school hosts its own American football team, the Santa Death Parade, which shares its name with Charlie's mecha. Other notable features include tennis courts, weight rooms, a locker room, and a football stadium.
- After the duel with Charlie Macdonald, parts of the Santa Death Parade can be seen littered around campus. One of the robot's arms has actually demolished a good part of the main building, preventing Travis from taking the route he used to face Charlie.
|No More Heroes 2|
|Characters||Bishop Shidux · Cat Jeane · Dr. Naomi · Henry · Mask de Uh · Mimmy · Ryan · Sylvia Christel · Takashi Miike · Talbot and Weller|
|Assassins||Travis Touchdown · Shinobu · Skelter Helter · Nathan Copeland · Charlie Macdonald · Kimmy Howell · Matt Helms · Cloe Walsh · Dr. Letz Shake · Million Gunman · New Destroyman · Ryuji · Margaret Moonlight · Captain Vladimir · Alice Twilight · Jasper Batt, Jr.|
|Locations||Iron Claw Point · Destroy University · Santa Destroy Bank · Destroy Stadium · Destroy Resort · Motel "NO MORE HEROES" · Naomi's Lab · Ryan's Gym|
|Settlements||Santa Destroy, California · Akashic Points|
|Weapons||Beam katana · Three Girl Rhumba's Sword · Earthquake Maker · Vosmir · Shapeshifting boombox · Le Croissant du Angel|
|Robots||Santa Death Parade · Glastonbury|