|Affiliations||United Assassins Association (Ranked 25th)|
|Ranking match||Destroy University|
|Weapon||Santa Death Parade|
|First appearance||No More Heroes 2: Desperate Struggle|
|Battle theme||Death Parade March|
|Voice actor||Yuri Lowenthal|
Charlie MacDonald is an assassin ranked 25th by the UAA. The girls on his cheerleading squad (that Travis refers to collectively as Charlie's "hoes") each occupy slots 26-49 on the same list. Not much else is known other than the fact that Charlie is the star quarterback of Destroy University's football team, and that he is so attractive that girls just seem to flock to him. Together, Charlie and the cheerleaders can summon and pilot the Santa Death Parade, a giant laser-firing robot.
The battle ends when Travis damages the Santa Death Parade's power system. Travis' mecha, Glastonbury, then throws Charlie and the cheerleaders into space, where he obliterates them with his buster cannon. Charlie and the cheerleaders are never heard from again.
- Before facing Kimmy Howell, parts of the Santa Death Parade can be spotted around the now-damaged Santa Destroy University.
- Excluding Jasper Batt Jr.'s battle, MacDonald has the only battle without any blood.
- Coincidentally, there is a English footballer who shares the same name as Charlie.
|No More Heroes 2|
|Characters||Bishop Shidux · Cat Jeane · Dr. Naomi · Henry · Mask de Uh · Mimmy · Ryan · Sylvia Christel · Takashi Miike · Talbot and Weller|
|Assassins||Travis Touchdown · Shinobu · Skelter Helter · Nathan Copeland · Charlie Macdonald · Kimmy Howell · Matt Helms · Cloe Walsh · Dr. Letz Shake · Million Gunman · New Destroyman · Ryuji · Margaret Moonlight · Captain Vladimir · Alice Twilight · Jasper Batt, Jr.|
|Locations||Iron Claw Point · Destroy University · Santa Destroy Bank · Destroy Stadium · Destroy Resort · Motel "NO MORE HEROES" · Naomi's Lab · Ryan's Gym|
|Settlements||Santa Destroy, California · Akashic Points|
|Weapons||Beam katana · Three Girl Rhumba's Sword · Earthquake Maker · Vosmir · Shapeshifting boombox · Le Croissant du Angel|
|Robots||Santa Death Parade · Glastonbury|